Can played in his favoured midfield position for the third game in a row after spend the whole of last season in defence.
The 21-year-old played alongside Lucas Leiva and James Milner in the centre of the park.
Can replaced Jordan Henderson who came off injured during last weekend’s victory over Bournemouth.
Ozil had a quite 90 minutes for the Gunners tonight following his staring role in the Gunners 2-1 victory over Crystal Palace in the previous round.
Kick-off: 20:00 (GMT)
Stadium: Emirates Stadium
Arsenal: Cech, Bellerin, Calum Chambers, Gabriel, Monreal, Coquelin, Cazorla, Sanchez, Mesut Özil, Ramsey, Giroud
Subs: Ospina, Gibbs, Debuchy, Arteta, Flamini, Chamberlain, Walcott
Liverpool: Mignolet, Clyne, Skrtel, Lovren, Gomez, Milner, Can, Lucas, Firmino, Coutinho, Benteke
Subs: Bogdan, Sakho, Moreno, Origi, Ings, Ibe, Rossite