Gunners boss Arsene Wenger will also be keen on ending his 12 game winless run against Chelsea manager Jose Mourinho.
Wenger could be without Per Mertesacker due to injury. Gabriel Paulista may start alongside Laurent Koscielny in defence.
Arsenal will also be without Mikel Arteta and Alex Oxlade-Chamberlain due to injury.
Mesut Özil is expected to start for the Gunners. Arsenal have won 14 out of their last 16 games in which the 26-year-old has played.
Mourinho may take a risk with Diego Costa after recovering from a hamstring injury but Didier Drogba will be more likely to start upfront.
Former Arsenal midfielder Cesc Fabregas is expected to start and could get a frosty reception from the home crowd.
Arsenal – Chelsea
Referee: Michael Oliver
Kick-Off: 16:00 GMT
Arsenal possible starting lineup:
Ospina, Bellerin, Koscielny, Gabriel, Monreal, Coquelin, Cazorla, Ramsey, Özil, Sanchez, Giroud
Manager: Arsene Wenger
Chelsea possible starting lineup:
Courtois, Ivanovic, Terry, Cahill, Azpilicueta, Zouma, Matic, Willian, Fabregas, Hazard, Drogba
Manager: Jose Mourinho