Gunners boss Arsene Wenger is expected to start Mesut Özil after he scored his second goal in as many big games midweek against Bayern Munich.
The north London based side will be in high spirits after beating Bayern 2-0 in the Champions League and are also in great form in the league.
Arsenal are expected to be without Aaron Ramsey, Jack Wilshere, Danny Welbeck and Tomas Rosicky against the Toffees.
The Gunners have won nine out of the last 16 games against Everton in the Premier League.
Arsenal v Everton
Kick-Off: 17:00 GMT
Arsenal possible starting lineup: Cech; Bellerin, Mertesacker, Koscielny, Monreal; Coquelin, Arteta; Cazorla, Ozil, Sanchez; Giroud
Everton possible starting lineup: Howard; Coleman, Jagielka, Stones, Galloway; McCarthy, Barry; Lennon, Barkley, Naismith; Lukaku