The 27-year-old missed the Gunners 0-0 draw with Hull City due to an illness but has been cleared fit by Arsene Wenger.
Barcelona star Arda Turan will mess the encounter due to a suspension.
Ozil, Joel Campbell and Olivier Giroud will have to be on their best behaviour considering all three are one booking away from a suspension.
The World Cup winner has six goals in all competitions and 17 assists in the Premier League – the highest in the league.
Arsenal v Barcelona
Stadium: Emirates Stadium
Arsenal probable starting line up: Cech, Bellerin, Mertesacker, Koscielny, Monreal, Ramsey, Coquelin, Walcott, Ozil, Sanchez, Giroud
Barcelona probable starting line up: Ter Stegen; Alves, Mascherano, Pique, Alba; Rakitic, Busquets, Iniesta; Messi, Suarez, Neymar