Chelsea are first in the Premier League, 10 points ahead of Arsenal with six matches to go.
The Blues could clinch the title if they beat the Gunners and the following game against Leicester City mid-week.
Arsenal are currently second and have a mathematical chance of keeping their title hopes alive with a win against Mourinho’s side.
Mesut Özil will start the the Gunners and has worked with Mourinho in the past.
The World Cup winner had 81 assists in all competitions and won the La Liga title at Real with Mourinho as manager.
Arsenal – Chelsea
Referee: Michael Oliver
Kick-Off: 16:00 GMT
Ospina, Bellerin, Mertesacker, Koscielny, Monreal, Coquelin, Cazorla, Ramsey, Özil, Alexis, Giroud
Subs: Szczesny, Debuchy, Gibbs, Wilshere, Walcott, Flamini, Welbeck
Manager: Arsene Wenger
Courtois, Ivanovic, Cahill, Terry (c), Azpilicueta, Matic, Fabregas, Ramires, Oscar, Willian, Hazard
Subs: Cech, Filipe Luis, Zouma, Mikel, Loftus-Cheek, Cuadrado, Drogba
Manager: Jose Mourinho