The North London based side take on Hull for the third consecutive season in the Cup. Arsenal came back from 2-0 down to beat Hull in the 2014 final.
Arsenal will be looking to build upon their 2-1 win over Leicester City last weekend.
Ozil provided the assist for the Gunners last second goal which saw them cut the gap between themselves and league leaders down to two points.
The 27-year-old has been in impressive form this season with six goals in all competitions as well as 17 assists in the Premier League.
Arsenal v Hull
Kick-Off: 12:45 (GMT)
Stadium: Emirates stadium
Arsenal confirmed starting line-up: Ospina, Chambers, Mertesacker, Koscielny, Gibbs, Flamini, Elneny, Campbell, Iwobi, Walcott, Welbeck
Hull confirmed startlin line-up: Jakupović, Davies, Bruce, Maguire, Tymon, Taylor, Meyler, Maloney, Elmohamady, Powell, Diomande