Can has started on the bench for Liverpool’s opening two games of the season but has been included in the Red’s midfield following an injury to Jordan Henderson.
Henderson came off injured during last weekend’s victory over Bournemouth and has been left out of today’s squad.
Mesut Özil starts again following his staring role in the Gunners 2-1 victory over Crystal Palace in the previous round.
The Germany international also scored and provided an assist when Arsenal hosted Liverpool last season.
Kick-off: 20:00 (GMT)
Stadium: Emirates Stadium
Arsenal: Cech, Bellerin, Calum Chambers, Gabriel, Monreal, Coquelin, Cazorla, Sanchez, Mesut Özil, Ramsey, Giroud
Subs: Ospina, Gibbs, Debuchy, Arteta, Flamini, Chamberlain, Walcott
Liverpool: Mignolet, Clyne, Skrtel, Lovren, Gomez, Milner, Can, Lucas, Firmino, Coutinho, Benteke
Subs: Bogdan, Sakho, Moreno, Origi, Ings, Ibe, Rossiter