Can has started on the bench for Liverpool’s opening two games of the season but has been tipped to start tonight following an injury to Jordan Henderson. The 21-year-old will play in his favoured midfield position if selected.
Henderson came off injured during last weekend’s victory over Bournemouth and is a major doubt for tonights game.
Mesut Özil is expected to start again following his staring role in the Gunners 2-1 victory over Crystal Palace in the previous round.
The Germany international also scored and provided an assist when Arsenal hosted Liverpool last season.
Kick-off: 20:00 (GMT)
Stadium: Emirates Stadium
Arsenal: Cech, Bellerin, Mertesacker, Koscielny, Monreal, Coquelin, Cazorla, Sanchez, Mesut Özil, Ramsey, Giroud
Liverpool: Mignolet, Moreno, Skrtel, Lovren, Clyne, Milner, Emre Can, Lallana, Coutinho, Ibe, Benteke