The Gunners have the opportunity to go four points clear of City and get be within two points of leaders Leicester City with a win.
Arsenal go into the game in an impressive run of form which has seen them win their last two league games and secure a place in the Last 16 of the UEFA Champions League.
Özil is has won the Arsenal Vitality Player of the Month award for the past two consecutive months. Ozil is currently the leading assist provider in Europe after assisting 13 goals for Arsenal in 15 Premier League games.
Arsenal v Manchester City
Kick-Off: 20:00 (GMT)
Stadium: Emirates Stadium
Arsenal probable starting line-up: Cech; Bellerin, Mertesacker, Koscielny, Monreal, Ramsey, Flamini; Campbell, Ozil, Walcott; Giroud
Manchester City probable starting line-up: Hart; Sagna, Otamendi, Mangala, Clichy; Fernandinho, Toure; De Bruyne, Silva, Sterling; Aguero