The Gunners are currently in sixth place on 13 points but a win would take Arsenal into joint second place alongside United.
Arsenal star Mesut Özil will start despite a disappointing performance in the 3-2 loss to Olympiakos in the UEFA Champions League. Petr Cech also returns to the side replacing David Ospina in goal.
The North London based club will be without Laurent Koscielny Mikel Arteta and Flamini due to injuries while Ander Herrera and Marcos Rojo are out for United.
Arsenal beat United 2-1 in the FA Cup quarter-finals the last time these two sides met but the Red Devils did beat the Gunners 2-1 the last time they met at the Emirates.
Arsenal v Manchester United
Kick-Off: 16:00 GMT
Arsenal confirmed starting lineup: Cech, Bellerin, Mertesacker, Gabriel, Monreal, Coquelin, Cazorla, Ramsey, Ozil, Sanchez, Walcott
Subs: Ospina, Giroud, Campbell, Chamberlain, Gibbs, Debuchy
Manager: Arsene Wenger
Manchester United confirmed starting lineup: De Gea, Young, Smalling, Blind, Darmian, Carrick, Schweinsteiger, Mata, Rooney, Memphis, Martial
Subs: Romero, Jones, McNair, Schneiderlin, Valencia, Fellaini, Wilson
Manager: Louis van Gaal