The Gunners will be without Laurent Koscielny due to injury which means that Per Mertesacker is likely to start alongside Gabriel in defence.
Mikel Arteta and Flamini are also out with injuries for the North London based side while Ander Herrera and Marcos Rojo are out for United.
Arsenal star Mesut Özil is expected to start and will be hoping to win back the favour of the home faithful after a disappointing performance against the Greek giants in the Champions League.
The Gunners are currently fourth in the Premier League but could move into second place with a win depending on other results.
Arsenal v Manchester United
Kick-Off: 16:00 GMT
Arsenal possible starting lineup: Cech, Bellerin, Mertesacker, Gabriel, Monreal, Coquelin, Cazorla, Ramsey, Ozil, Sanchez, Walcott
Manager: Arsene Wenger
Manchester United possible starting lineup: De Gea, Valencia, Smalling, Blind, Darmian, Schneiderlin, Carrick, Mata, Rooney, Memphis, Martial
Manager: Louis van Gaal