The Gunners have won seven and lost none of their last 10 Premier League matches against Sunderland but will be without Mathieu Debuchy, Danny Welbeck and Alex Oxlade-Chamberlain.
Arsene Wenger has named an unchanged starting lineup in his last six games but has opted to field Jack Wilshere in place of Francis Coquelin.
Mesut Özil will make his 30th appearance of the season for the Gunners tonight.
Arsenal will be hoping Olivier Giroud keeps up his good form against Sunderland, the Frenchman has scored three goals in four Premier League games against the Black Cats.
Referee: Anthony Taylor
Kick-Off: 20:00 GMT
Arsenal: Ospina, Bellerin, Mertesacker, Koscielny, Gibbs, Ramsey, Cazorla, Wilshere, Ozil, Alexis, Giroud
Subs: Szczesny, Gabriel, Monreal, Coquelin, Flamini, Rosicky, Walcott
Sunderland: Pantilimon, Jones, van Aanholt, O’Shea (c), Coates, Cattermole, Larsson, Johnson, Graham, Defoe, Wickham
Subs: Rodwell, Fletcher, Reveillere, Giaccherini, Vergini, Buckley, Mannone