The Gunners have won seven and lost none of their last 10 Premier League matches against Sunderland but will be without Mathieu Debuchy and Alex Oxlade-Chamberlain but Danny Welbeck could return after missing the last three matches due to knee injury.
Arsene Wenger has named an unchanged starting lineup in his last six games but he could use Theo Walcott after his performance against Manchester United in the 1-1 draw.
Mesut Özil is expected to make his 30th appearance of the season for the Gunners.
Arsenal will be hoping Olivier Giroud keeps up his good form against Sunderland, the Frenchman has scored three goals in four Premier League games against the Black Cats.
Arsenal v Sunderland
Referee: Anthony Taylor
Kick-Off: 20:00 GMT
Arsenal expected starting lineup:
Ospina; Bellerin, Mertesacker, Koscielny, Monreal; Coquelin, Cazorla; Ramsey, Ozil, Alexis; Giroud
Sunderland expected starting lineup:
Pantilimon; Reveillere, O’Shea, Coates, Van Aanholt; Bridcutt, Cattermole, Larsson; Defoe, Fletcher, Wickham