Theo Walcott, Jack Wilshere, Mesut Özil, Ospina, Mikel Arteta and Debuchy could all miss Arsenal’s Champions League Group D clash with Galatasaray.
Wenger confirmed that Walcott will definitely miss the game.
“Walcott has an injection today so he will not play. Galatasaray is also too early,” Wenger said.
Jack Wilshere and Mesut Özil are out until the new year.
Arsenal are already through to the next round however, were they to beat Galatasaray and if Anderlecht beat Borussia Dortmund the Gunners would clinch first place.
The Gunners beat Galatasaray 4-1 at the Emirates in the first leg and the Lions are yet to win a single game in this seasons competition.
Galatasaray are undefeated in their last five home games against English visitors, winning three and drawing two.
The Lions overall home record against Premier League sides is W3 D4 L2.