The Gunners are in need of a miracle after suffering a disappointing at the hands of the La Liga giants at the Emirates. Barcelona recorded a 2-0 win with both goals coming from Leonel Messi.
Arda Turan is expected to make his first Champions League start for Barcelona after scoring an over-head kick during his sides 6-0 win over Getafe.
Arsenal boss Arsene Wenger is expected to field his strongest side despite the task at hand. Mesut Ozil is set to start in his favoured number ten position behind Olivier Giroud.
The 27-year-old has provided 19 assists and seven goals in 36 appearances for Arsenal this season.
Barcelona v Arsenal
Kick-Off: 19:45 (GMT)
Stadium: Camp Nou
Barcelona probable starting lineup: Stegen, Alves, Mascherano, Mathieu, Alba, Rakitic, Busquets, Iniesta, Messi, Suarez, Neymar
Arsenal probable starting lineup: Ospina, Monreal, Koscielny, Mertesacker, Bellerin, Coquelin, Elneny, Sanchez, Ozil, Welbeck, Giroud