The game will hold special importance for Arda Turan who joined Barcelona from Atletico Madrid over the summer transfer window.
Turan became a household name in Spain at Atleti under the stewardship of Diego Simeone since joining in 2012.
The bearded winger was a star in Simeone’s side epitomising his hard working style and discipline.
Barcelona are unbeaten in their last 25 games and have won all seven games since Turan made his debut for the club against Espanyol in the Spanish Cup.
Turan has missed just one game in Barcelona’s last seven matches and that was as a result of having the flu.
Barcelona will be without Marc Batra, Jordi Masip, Sandro Ramírez and Adriano Correia are all out and Neymar is a doubt.
Barcelona – Atletico Madrid
Stadium: Camp Nou
Kick-Off: 15:00 GMT
Barcelona (4-3-3): Bravo; Alves, Piqué, Mascherano, Alba; Busquets, Rakitic, Iniesta; Messi, Suárez, Neymar
Manager: Luis Enrique
Atlético Madrid (4-4-2): Oblak; Juanfran, Giménez, Godín, Luís; Ñíguez, Fernández, Gabi, Koke; Vietto, Griezmann
Manager: Diego Simeone