Barcelona will be hoping to join Leicester City as the only other side in the Champions League to have won 100 percent of their first three group games with a victory over Manchester City at the Camp Nou.
Barca boss Luis Enrique has made a few changes to the side that beat Deportivo La Coruna 4-0 in the La Liga over the weekend.
Arda Turan – who was deployed as a right-back – has been left on the bench. The MSN – Messi, Suarez, Neymar – will start and the midfield trio will comprise of Iniesta, Rakitic and Sergio.
Manchester City boss Pep Guardiola knows Barcelona all too well from his time as a player and manager at the club.
Guardiola will be without Sergio Aguero who is out but Kevin De Bruyne is back and will start. Germany international of Turkish origin Ilkay Gundogan has also been included in the starting lineup.
Barcelona confirmed line-ups: 1.Ter Stegen 3.Piqué 4.Rakitic 5.Sergio 8.Iniesta 9.Suárez 10.Messi 11.Neymar Jr 14.Mascherano 18.J.Alba 23.Umtiti
Subs: 25. Masip 7. Arda 12. Rafinha 17. Alcácer 19. Digne 21. André Gomes 24. Mathieu
Manchester City confirmed line-ups: Bravo, Zabaleta, Otamendi, Stones, Kolarov, Fernandinho, Gundogan, Silva, Sterling, Nolito, De Bruyne
Subs: Caballero, Fernando, Aguero, Maffeo, Clichy, Sane, Navas