Bayer Leverkusen host Barcelona at the BayArena needing a victory to stand any chance of making it through to Champions League Last 16 spot.
Leverkusen are currently in join second place in Group B on five points with Italian giants Roma who take on BATE in the other group game.
Barcelona are already through in first place with 13 points and as a result will play a rotation side with only a few first team players in the starting line-up however, Lionel Messi will start.
The reigning Champions League title holders will be without Arda Turan who is still restricted from playing due to the FIFA transfer ban imposed on the club.
Turkish international Hakan Çalhanoğlu will start for Bayer as will Ömer Toprak and has been one of the Bundesliga outfits most in form of players in Europe this season.
Leverkusen v Barcelona
Kick-Off: 19:45 GMT
Leverkusen: Leno, Tah, Hilbert, Wendell, Ömer, Hakan, Kramer, Bellarabi, Kampl, Mehmedi, Hernández
Out: Jedvaj (thigh), Bender (ankle)
Barcelona: 1. Ter Stegen, 4. Rakitic, 10. Messi, 15. Bartra, 17. Munir, 18. Jordi Alba, 19. Sandro, 21. Adriano, 23. Vermaelen, 26. Samper, 34. Kaptoum
Out: Alves (suspended), Douglas (foot), Rafinha (knee), Mathieu (muscular), Sergi Roberto (ankle), Iniesta (rested), Piqué (rested)
Subs: 13. Bravo, 5. Sergio, 9. Suárez, 14. Mascherano, 25. Masip, 27. Cámara, 28. Gumbau