Beşiktaş goalkeeper Tolga Zengin sustained an injury during the 3-2 win over Bursaspor in the Süper Lig.
The Black Eagles moved into 1st place in the Süper Lig with 47 points following the victory.
The Turkish international keeper will be out for four weeks according to Lig Tv.
Zengin will miss the mid-week Europa League Round of 32 clash against Liverpool due to injury.
The experienced keeper conceded 23 times in 27 appearances for the Black Eagles this season and kept nine clean sheets.
Zengin will be replaced by 26-year-old Cenk Gönen. The Turkish international keeper has conceded 10 times in 10 games and kept a total of two clean sheets this season.
Beşiktaş travel to England take on Liverpool at Anfield on Thursday 19 February 2015 for the first leg.
The second-leg will be played on Thursday 26 February at the Atatürk Olympic stadium.
The stadium is where the Reds beat AC Milan to lift the 2005 Champions League.