The home side will have to do without their in-form winger Gokhan Tore who picked up a suspension in his sides 3-2 defeat against Erciyesspor on Monday.
Manager Slaven Bilic is expected to field Kerim Frei in his place. The former Fulham man impressed Bilic on Monday with a brace against Erciyesspor.
Fenerbahce are yet to win a game away from home this season but will be boosted by the news that both Emre and Emenike have passed late fitness tests to make the starting line-up.
Bruno Alves misses the game due to the red card he picked up in the intercontinental derby against Galatasaray,
Besiktas: Tolga Zengin, Necip Uysal, Ersan Adem Gülüm, Pedro Franco, Motta, Veli Kavlak, Atiba Hutchinson, Olcay Şahan, Oğuzhan Özyakup, Kerim Frei Koyunlu, Demba Ba.
Fenerbahce: Volkan Demirel, Gökhan Gönül, Bekir İrtegün, Kadlec, Caner Erkin, Mehmet Topal, Meireles, Emre Belözoğlu, Kuyt, Sow, Emenike.