Beşiktaş will be without Necip Uysal, Serdar Kurtuluş and Veli Kavlak going into the Trabzonspor clash.
Uysal is suspended after picking up a direct red card in the 2-1 win over Karabükspor.
Kurtuluş is also suspended after picking up an accumulation of yellow cards.
Veli Kavlak will also miss the game due to injury while first choice keeper Tolga Zengin is also out.
Zengin will not return until the end of the season and Cenk Gönen only recently recovered from an injury setback.
Despite recovering from injury Gönen has been kept out of the starting lineup by third choice keeper Günay Güvenç who has been in impressive form since making a substitute appearance in the Istanbul derby against Fenerbahçe.
Beşiktaş manager Slaven Bilic will have to juggle his team selection due to the injuries and suspensions.
The Croatian coaches main concern is the foreign player ruling, Bilic may have to sacrifice experienced defender Sivok or in form playmaker Jose Sosa.