The reigning Premier League champions are under a lot of pressure after dropping into 15th place and Jose Mourinho could face the axe should the Blues lose against Liverpool.
The Reds meanwhile are hoping for their first league win under the stewardship of Jurgen Klopp.
Emre Can is expected to keep his place in the team against the London based club after starting every game under the stewardship of his new head coach.
Chelsea may be in poor form but have not lost against Liverpool at home in their last six meetings at Stamford Bridge.
Chelsea v Liverpool
Kick-Off: 12:45 GMT
Stadium: Stamford Bridge
Chelsea possible starting lineup: Begovic; Azpilicueta, Cahill, Terry, Zouma; Matic, Fabregas; Willian, Hazard, Pedro; Costa
Manager: Jose Mourinho
Liverpool possible starting lineup: Mignolet; Moreno, Skrtel, Sakho, Clyne; Can, Lucas, Milner; Coutinho, Lallana; Benteke
Manager: Jurgen Klopp