West Ham travel to Stamford Bridge for their first Premier League game of the season in the London derby.
The Italian manager has however, won league titles in his last three domestic campaigns for Serie A giants Juventus.
Bilic welcomes back summer signing Gokhan Tore who is on course for a memorable debut against his former team.
Tore was a Chelsea youth product joining the club aged 16 before rising up the ranks prior to his move to HSV Hamburg.
The Turkish international winger is available as are fellow summer signings Ayew, Feghouli, Nordtveit and Masuaku.
Bilic will be without Manuel Lanzini and left back Aaron Cresswell who are both injured.
Chelsea v West Ham
Kick-Off: 20:00 GMT
Stadium: Stamford Bridge
Chelsea – Probable lineup (4-2-3-1): Courtois (GK), Ivanovic, Terry, Cahill, Azpilicueta; Kante, Fabregas; Hazard, Oscar, Willian; Costa
Manager: Antonio Conte
West Ham – Probable lineup (4-2-3-1): Adrian (GK), Byram, Obgonna, Reid, Antonio; Noble, Kouyate; Payet, Ayew, Tore; Carroll
Manager: Slaven Bilic