Beşiktaş striker Demba Ba, fullback Ismail Koybaşı and winger Kerim Frei are one yellow card away from picking up an automatic suspension.
The Black Eagles trio will miss the game against Akhisar next week if any of them are booked against Gaziantepspor.
Ba has 25 goals and seven assists in all competitions this season.
The Senegalese international has achieved a personal record of scoring 17 league goals in one season.
Only Bursaspor striker Fernandao has more Süper Lig goals this season.
Koybaşı recently returned from injury and is unlikely to receive much playing time against the Falcons.
Frei is unlikely to start but is expected to make an appearance against Gaziantepspor.
Beşiktaş are currently second in the Süper Lig, one point ahead of third placed Fenerbahçe.
Galatasaray are three points ahead of the Black Eagles but have a game in hand. Beşiktaş will overtake the Lions on goal difference with a win over Gaziantepspor.