Fenerbahçe defender Egemen Korkmaz and midfielder Diego Ribas have been left out of the squad that will travel to the Black Sea ahead of the Rizespor game.
Korkmaz and Ribas both picked up injuries during training and will both miss the trip.
The Turkish international defender had only just recovered from a lengthy injury that forced him onto the sidelines for the last few months.
Emmanuel Emenike is also expected to miss the game after falling out with Fenerbahçe supporters in the Istanbul derby against Beşiktaş before the international break.
Fenerbahce sit in 3rd place with 53 points following 16 wins, five draws and four defeats in 25 games.
Rizespor are currently 13th in the league and have seven victories, seven draws and 11 defeats.
The Black Sea based side are undefeated in their last four games but have not beat Fenerbahçe since 2007.
The Yellow Canaries beat Rizespor earlier on in the season by a 2-1 scoreline.