Dortmund beat Anderlecht 3-0 win on matchday two and will be hoping to repeat a similar scoreline in Germany.
Jurgen Klopp will be without Kehl, Reus, Papastathopoulos and Şahin due to injury.
Anderlecht also have a number of injury concerns Suárez, Nuytinck and Najar and all out against Dortmund.
The Belgium club have already secured a place in the Europa League but cannot make the Champions League Last 16.
Confirmed Starting XI’s:
Dortmund: Langerak – Durm, Subotic, Ginter, Schmelzer – Sahin, Gündogan – Großkreutz, Kagawa, Mkhitaryan – Immobile
Anderlecht: Proto; Vanden Borre, Mbemba, Deschacht, N’Sakala; Dendoncker, Kljestan; Acheampong, Praet, Conté; Mitrović.