The Bundesliga giants host the Red’s at the Signal Iduna Park in the Europa League, kick-off is at 20:05.
Can has been included in Liverpool’s midfield and starts alongside Jordan Henderson and James Milner.
Dortmund skipper Mats Hummels has made a return tp the starting line-up after sitting out Saturday’s win over Werder Bremen.
Gundogan has seven assists and three goals in 36 appearances for Dortmund this season.
Dortmund v Liverpool
Kick-Off: 20:05 (GMT)
Stadium: Signal Iduna Park
Dortmund confirmed line-up: Weidenfeller, Piszczek, Bender, Hummels, Schmelzer, Castro, Weigl, Durm, Mkhitaryan, Reus, Aubameyang
Subs: Bürki, Sahin, Ginter, Leitner, Pulisic, Sokratis, Kagawa
Liverpool confirmed line-up: Mignolet, Clyne, Lovren, Sakho, Moreno, Henderson, Can, Milner, Lallana, Coutinho, Origi
Subs: Ward, Toure, Smith, Allen, Ibe, Firmino, Sturridge.