Reds boss Brendan Rodgers is likely to switch to a three-back formation that served him well last season with Martin Skrtel, Sakho and Emre Can all healthy.
All three are expected to start in defence for Liverpool however, Can has played most of the current season as a midfielder. The 21-year-old is of course no stranger to the position having played in a back-three and as a full-back for most of last season.
Everton go into the game in 7th place in the Premier League, three sports above the Reds however, they have won just once in their last 17 derby matches. The last time Liverpool lost at Goodison Park was back in 2010.
Everton v Liverpool
Kick-Off: 13:30 GMT
Stadium: Goodison Park
Everton possible starting lineup: Howard; Coleman, Stones, Jagielka, Galloway; McCarthy, Barry; Deulofeu, Barkley, Naismith; Lukaku
Manager: Roberto Martinez
Liverpool possible starting lineup: Mignolet; Sakho, Skrtel, Can; Moreno, Lucas, Milner, Clyne; Coutinho; Ings, Sturridge
Manager: Brendan Rodgers