Arsene Wenger has picked a full strength side with Mesut Ozil and Alexis Sanchez in the starting line-up. January signing Elneny has kept his place in the team and will feature alongside Coquelin in midfield.
Olivier Giroud has been dropped for the second week running after a poor run of results and has been replaced with Welbeck.
Nigerian international Iwobi has also kept his place in the side after starting against Barcelona mid-week.
Everton v Arsenal
Stadium: Goodison Park
Kick-Off: 12:45 GMT
Everton confirmed XI: Joel, Baines, Funes Mori, Jagielka (c), Coleman, McCarthy, Bešić, Cleverley, Lennon, Barkley, Lukaku
Subs: Howard, Stones, Kone, Niasse, Deulofeu, Osman, Galloway
Arsenal confirmed XI: Ospina, Bellerin, Koscielny, Gabriel, Monreal, Coquelin, Elneny, Iwobi, Ozil, Alexis, Welbeck
Subs: Macey, Gibbs, Mertesacker, Chambers, Campbell, Walcott, Giroud
Manager: Arsene Wenger