Reds boss Brendan Rodgers has switched to a three-back formation that served him well last season with Martin Skrtel, Sakho and Emre Can all having been assigned a role in the defence.
Can has however, played most of the current season as a midfielder. The young defender-come-midfielder is familiar with the role having played as a back-three and as a full-back for most of last season and recently for the Germany national team.
The Toffees are currently in 7th place three sports above their cross-city rivals however, they have won just once in their last 17 derby matches and the last time the Reds lost at Goodison Park was back in 2010.
Everton v Liverpool
Kick-Off: 13:30 GMT
Stadium: Goodison Park
Everton confirmed starting lineup: Howard, Galloway, Funes Mori, Jagielka (c), Browning, Barry, McCarthy, Naismith, Barkley, Deulofeu, Lukaku
Subs: Robles, Gibson, Oviedo, Kone, Lennon, Osman, Holgate
Manager: Roberto Martinez
Liverpool confirmed starting lineup: Mignolet, Skrtel, Sakho, Can, Clyne, Moreno, Lucas, Milner, Coutinho, Ings, Sturridge
Subs: Bogdan, Gomez, Rossiter, Allen, Ibe, Lallana, Origi
Manager: Brendan Rodgers