Fenerbahçe take on Beşiktaş at the Atatürk Olympic stadium hoping to keep a grip on their position as Turkish Super League leaders.
Van Persie scored two minutes after his 77th minute introduction in the 2-1 win against Bursaspor last week with his first shot on target.
The experienced striker made it clear that he did not appreciate being left on the bench after the game but a bust-up was averted after sporting director Giulliano Terraneo intervened and brokered a peace deal between the manager and Van Persie.
Pereira has opted to use Fernandao ahead of Van Persie upfront going into the derby but will start the 32-year-old strikers former United teammate Luis Nani.
On-loan Liverpool winger Lazar Markovic has also been given a starting role after an impressive performance last week.
Beşiktaş will be fielding a similar side to last week with the only major difference being Olcay Şahan starting ahead of Ricardo Quaresma. Former Arsenal youth Oğuzhan Özyakup will return to the starting line-up after missing the 1-1 draw against Gençlerbirliği last week with injury.
Özyakup will start alongside Atiba Hutchinson in central midfield while Jose Sosa will be deployed in an attacking midfield role with Gökhan Töre and Şahan out wide. Germany international Mario Gomez will lead the charge upfront as the Black Eagles loan striker.
BEŞİKTAŞ – FENERBAHÇE
Stadium: Atatürk Olimpiyat
Kick-Off: 17:00 GMT
Referee: Halis Özkahya
Expected starting XI’s
BEŞİKTAŞ: Tolga, Beck, Rhodolfo, Ersan, Tosic, Oğuzhan, Atiba, Gökhan, Sosa, Olcay, Gomez
MANAGER: Şenol Güneş
FENERBAHÇE: Volkan, Şener, Kjaer, Alves, Caner, Mehmet Topal, Meireles, Ozan, Markovic, Nani, Fernandao
MANAGER: Vitor Pereira