United recorded a 4-1 victory over Fenerbahce giants a fortnight ago and will be eager to record another victory to alleviate the pressure building on the side following a poor run of results in the Premier League.
Jose Mourinho has decided to field a strong line-up with De Gea starting in goal and Wayne Rooney leading the attacking line. United side find themselves in eighth place in the league with 15 points after ten games.
Fenerbahce have also been struggling with their domestic form and are in fifth place, eight points behind leaders Istanbul Basaksehir.
Fenerbahce v Manchester United
Stadium: Şükrü Saracoğlu
Kick-Off: 18.00 (GMT)
Referee: Milorad Mazic
Fenerbahce: Volkan Demirel, Hasan Ali, Simon Kjaer, Martin Skrtel, Şener Özbayraklı, Mehmet Topal, Josef de Souza, Alper Potuk, Volkan Şen, Lens, Moussa Sow.
Manager: Dirk Advocaat
Manchester United: De Gea, Darmian, Rojo, Blind, Shaw, Schneiderlin, Herrera, Rashford, Pogba, Martial, Rooney.
Manager: Jose Mourinho