The Red Devils recorded a 4-1 victory over the Turkish Super League giants a fortnight ago and will be eager to record another victory to alleviate the pressure building on the side following a poor run of results in the Premier League.
Jose Mourinho’s side find themselves in eighth place in the league with 15 points after ten games.
Fenerbahce have also been struggling with their domestic form and are in fifth place, eight points behind leaders Istanbul Basaksehir.
Fenerbahce v Manchester United
Stadium: Ülker Stadyumu Fenerbahçe Şükrü Saracoğlu Spor Kompleksi
Kick-Off: 18.00 (GMT)
Referee: Milorad Mazic
Fenerbahce: Volkan Demirel, Şener Özbayraklı, Martin Skrtel, Simon Kjaer, Hasan Ali Kaldırım, Josef de Souza, Mehmet Topal, Volkan Şen, Alper Potuk, Jeremain Lens, Robin van Persie
Manager: Dirk Advocaat
Manchester United: Romero, Darmian, Blind, Jones, Shaw, Schneiderlin, Paul Pogba, Lingard, Rashford, Wayne Rooney, Zlatan Ibrahimovic
Manager: Jose Mourinho