Galatasaray have traditionally suffered in the absence of Felipe Melo over recent seasons.
The Lions have dropped eight points following Melo picking up an injury last month culminating with the 2-1 loss against Trabzonspor at the Avni Aker stadium.
Galatasaray have lost against rivals Fenerbahçe and drew against Başakşehirspor. The Istanbul giants have won their four other games without the Brazilian midfielder.
The Lions have lost 42 points over the past four seasons in games Melo has not played.
During the 2013-2014 season Melo missed four games due to suspensions. Galatasaray failed to win any of the games the tenacious midfielder missed.
Melo joined Galatasaray on a permanent deal from Juventus worth £3 million last summer after playing the previous two seasons on loan at the Lions.
The Brazilian midfielder has scored one goal in 22 appearances for Galatasaray in all competitors this season.