Hamzaoğlu spoke with GSTV ahead of the weekend fixture.
“We are aiming to win the the Super Lig and earn the club its forth star,” Hamzaoğlu said.
“The Besiktas game is very important for us. We have nothing to lose and out squad is strong and motivated for this games.
“Against Genclerbirligi we struggled to organise attacking moves. The pitch conditions did not help us when we were trying to defend the lead.”
Galatasaray take on Besiktas on Sunday at 17:00 GMT.
The Lions are unbeaten against Besiktas since April 2011.