Galatasaray take on Astana at the Türk Telekom Arena needing just a draw to take them to the Europa League Round of 32.
The Lions cannot book a place in the Champions League Last 16 and neither can Astana who are currently last place in Group C just one point behind Galatasaray.
The Istanbul giants will be without long term absentee Hamit Altıntop but Carole and on-loan Manchester City defender Jason Denayer are also out.
Captain Selçuk İnan was a doubt going into the game as was defender Hakan Balta but both have passed late fitness tests.
The visitors have no injuries or suspensions going into the clash against the Istanbul giants and have been training in the city for the last 10 days so will be well acclimatised.
Galatasaray v Astana
Stadium: Türk Telekom Arena
Galatasaray: Muslera, Sabri, Semih, Chedjou, Hakan, Olcan, Selçuk, Podolski, Sneijder, Yasin, Burak.
Out: Hamit Altıntop (knee), Carole (hamstring), Denayer (knee)
Astana: Eric, Anicic, Ilic, Postnikov, Shomko, Maksimovic, Kethevoama, Muzhikov, Canas,Twumasi,Kabananga