The Lions are still in search of their first win under the stewardship of Jan Olde Riekerink who recently replaced Mustafa Denizli as head coach.
Fenerbahce meanwhile will be hoping to return to winning ways after suffering a surprise defeat at the hands of Konyaspor over the weekend.
The Yellow Canaries will be without Caner Erkin who has been dropped after an altercation with head coach Vitor Pereira. Hasan Ali will replace the Turkish international as left-back.
Fenerbahce will also be without on-loan Liverpool winger Lazar Markovic who is out injured.
GALATASARAY – FENERBAHÇE
Stadium: Türk Telekom Arena
Referee: Mete Kalkavan
Kick-Off: 19:30 (Local Time)
Galatasaray: Muslera, Semih Kaya, Jason Denayer, Hakan Balta, Olcan Adın, Ryan Donk, Selçuk, Yasin, Emre, Sneijder, Podolski
Manager: Jan Olde Riekerink