Galatasaray will be without captain Selçuk İnan against Arsenal due to suspension.
The Turkish international midfielder was sent off on Match Day 5 in the 2-0 loss against Anderlecht.
Brazilian midfielder Felipe Melo is expected to return to the starting lineup after missing the 2-1 win over Akhisar in the Süper Lig on the weekend.
Manager Hamza Hamzaoğlu could have Swiss international Blerim Dzemaili back after recovering from injury but also has a choice of Hamit Altıntop, Emre Çolak and and Yekta Kurtuluş in midfield.
Wesley Sneijder is almost certain to start and will be playing in the hole behind Burak Yılmaz or Umut Bulut. Bruma and Olcan Adın could start on the wings.
Galatasaray have no chance of securing a place in the Champions League Last 16 or qualifying for the Europa League.
The Lions will be playing for pride however, have a good record against English opposition in Istanbul.
Galatasaray are undefeated in their last five home games against English visitors, winning three and drawing two.