Neville stated that he was not expecting Can to feature in Brendan Rodgers back-four against Newcastle United.
“We have not seen him play as a centre back in a back four, it is obviously different, he did very good as a centre back in a back three but I am surprised he has gone with Can in a back four at centre back,” Neville said speaking on Sky Sports 1.
Can signed for Liverpool as a central midfielder from Bayer Leverkusen in the summer but has played predominantly as a centre-back in the Reds back-three.
The 21-year-old will feature in a defensive back-four for the first time this season.
Rodgers has been forced to change his usual back-three of Martin Skrtel, Mamadou Sakho and Can due to injury and suspension.
Skrtel is out suspended while Sakho is out injured with a hamstring injury.
Liverpool captain Steven Gerrard is also suspended for the Reds.
Rodgers has decided to opt for a defensive line including Can and Dejan Lovren at centre-back while Moreno and Johnson will start as fullbacks.