Champions League Group D leaders Borussia Dortmund take on second placed Arsenal while Galatasaray will hope to overtake third-placed Anderlecht when the two sides meet in Belgium.
Dortmund have won all four group games, only conceding once along the way and have already secured a place in the Last 16. The Bundesliga outfit will clinch the group with a draw against Arsenal.
Arsenal will progress to the next round for the 15th time in a row with a draw, or if the score between Galatasaray and Anderlecht stays level. The Gunners will however, have to beat Dortmund as well as Galatasaray on Match Day 6 and hope Die Borussen lose against Anderlecht in the final game.
Dortmund beat Arsenal 2-0 in the opening group game but both sides are struggling at home. Dortmund are in 16th place in the Bundesliga and the Gunners have made their worst Premier League start, with 17 points from 12 games
Galatasaray are currently last with one point but could still make it to the next round. The Lions need to win, hope that Arsenal lose and then beat the Premier League outfit on the final group game by a scoreline that gives them the head-to-head advantage.
Anderlecht meanwhile need to beat the Lions as well as Dortmund and hope that Arsenal does not pick up another point.
The Belgium side would however, clinch a guaranteed Europa League spot if they beat Galatasaray.