The 27-year-old sat out of Arsenal’s defeat at the hands of Liverpool last week after being given an extended break following Euro 2016.
Laurent Koscielny has been rushed back but Ozil and Olivier Giroud will be on the bench going into the game.
Ozil missed the first Premier League game of the season against Liverpool which saw the Gunners lost 4-3 against at the Emirates.
Leicester City boss Claudio Ranieri meanwhile has not included Switzerland international Gokhan Inler in the match-day squad.
Leicester City v Arsenal
Kick-Off: 12:45 (GMT)
Stadium: King Power stadium
Leicester City confirmed line up: Schmeichel; Simpson, Huth, Morgan (c), Fuchs; Mahrez, Drinkwater, Mendy, Albrighton; Okazaki, Vardy
Subs: Hernandez, Musa, King, Amartey, Zieler, Gray, Ulloa
Manager: Claudio Ranieri
Arsenal confirmed line up: Cech, Bellerin, Holding, Koscielny, Monreal, Xhaka, Coquelin, Walcott, Cazorla, Ox, Alexis
Subs: Ospina, Gibbgs, Wilshere, Giroud, Ozil, Chambers, Elneny
Manager: Arsene Wenger