Can is unlikely to be tired considering he started against England and only played the last 20 minutes in the 4-1 win over Italy.
The 22-year-old has been one of Jurgen Klopp’s most trusted players in midfield starting just about every game he has been available for.
The Reds are currently seven points off a Champions League spot but take on second placed Tottenham who are still very much in the title race.
Liverpool have an impressive record against Tottenham having won four out of their last five Premier League meetings against Spurs.
Liverpool v Tottenham
Kick-off: 17:30 GMT
Liverpool possible starting lineup:
Mignolet; Flanagan, Lovren, Sakho, Moreno; Milner, Henderson, Can; Lallana, Coutinho, Sturridge
Manager: Jurgen Klopp
Tottenham possible starting lineup:
Lloris; Walker, Alderweireld, Wimmer, Rose; Dembele, Dier, Lamela, Eriksen, Alli; Kane
Manager: Mauricio Pochettino