Reds star Emre Can is set to start his first game since being involved in the Germany clash against France at the Stade De Paris when the attacks in the French capital took place.
Liverpool will be without Jordan Henderson and Joe Flanagan as well as defender Mamadou Sakho.
The home side are likely to be without star players Sergio Aguero and David Silva while Vincent Company, Fabian Delh, Samir Nasri, Pablo Zabaleta and Wilfried Bony remain doubts.
City are unbeaten at home against the Reds in their last six Premier League games and have won 12 of their last 13 home matches.
Manchester City v Liverpool
Kick-Off: 17:30 GMT
Manchester City Expected Line-up:
Hart, Kolarov, Kompany, Otamendi, Sagna, Fernando, Fernandinho, Kevin de Bruyne, Toure, Navas, Sterling
Liverpool Expected Line-Up:
Mignolet, Clyne, Skrtel, Lovren, Moreno, Leiva, Can, Milner, Coutinho, Lallana / Firmino, Benteke