Jurgen Klopp is set to rotate his squad following Friday’s 2-1 victory over Chelsea in the Premier League.
Can is expected to start in midfield after recovering from an ankle injury he suffered during Liverpool’s win over Burton in the League Cup.
The Germany international may however find it difficult to break into the side on a regular bases with Jordan Henderson, Gini Wijnaldum and Adam Lallana in such good form.
Lucas Leiva is once again set to start out-of-position in defence as the German tactician struggles to find cover in defence.
Liverpool take on the newly promoted Hull City in the Premier League on Saturday as they will look to record their third win in a row.
Liverpool probable staring line-up:
Karius, Clyne, Matip, Lucas, Moreno, Can, Grujic, Lallana, Coutinho, Ejaria, Origi.