Liverpool drew the first leg with Augsburg 0-0 at the WWK Arena. The Germany international of Turkish origin made the highest number of passes in midfield (63) at an 89 percent accuracy.
Can is set to be deployed in midfield alongside Jordan Henderson and James Milner.
Augsburg was founded over 100 years ago but did not play in the Bundesliga until 2011. This is the Bundesliga sides first season in European competition.
Can has provided one assist and scored two goals in 33 appearances for Liverpool this season.
Liverpool v Augsburg
Kick-Off: 18:00 (GMT)
Augsburg confirmed starting line-up: Hitz; Verhaegh, Janker, Klavan, Stafylidis; Feulner, Kohr; Esswein, Altintop, Werner; Bobadilla.
Liverpool confirmed starting line-up: Mignolet, Clyne, Toure, Sakho, Moreno, Henderson, Can, Milner, Coutinho, Firmino, Sturridge.