Reds midfielder Emre Can will make his league return after missing the last few weeks with injury and suspension.
Jurgen Klopp revealed before the match that he could give Can a start Chelsea in his pre-match press conference but also stated that he would not rush the midfielder back unless he was 100 percent.
Chelsea boss Guus Hiddink has made a number of changes to his squad following a long list of suspensions after the Tottenham clash last week with Diego Costa failing to make the team.
Liverpool have not beat Chelsea at Anfield since 2012 but a win would move them just one point behind 6th placed West Ham.
Liverpool v Chelsea
Kick-Off: 20:00 GMT
Liverpool confirmed starting lineup:
Mignolet, Clyne, Toure, Lovren, Moreno, Can, Milner, Lallana, Coutinho, Firmino, Sturridge
Subs: Bogdan, Skrtel, Smith, Lucas, Allen, Ojo, Benteke.
Manager: Jurgen Klopp
Chelsea confirmed starting lineup:
Begovic; Azpilicueta, Mikel, Cahill (c), Baba Rahman; Fabregas, Matic; Pedro, Willian, Hazard; Traore
Subs: Chelsea subs today: Amelia, Tomori, Kenedy, Loftus-Cheek, Palmer, Pato, Abraham.
Manager: Guus Hiddink