Reds star Emre Can could make his league return after missing the last few weeks with injury and suspension.
Can returned from injury sooner than expected in the 3-0 victory over Villarreal in the Europa League semi-final second-leg tie last Thursday.
Jurgen Klopp did hint that he could include Can in the squad against Chelsea in his pre-match press conference but also underlined that he would not rush him back unless he was fully fit.
The Reds have not beat Chelsea at Anfield since 2012 but a win would move them just one point behind 6th placed West Ham.
Liverpool v Chelsea
Kick-Off: 20:00 GMT
Liverpool possible starting lineup:
Mignolet; Flanagan, Skrtel, Toure, Randall; Allen, Can, Ojo, Firmino, Ibe; Benteke
Manager: Jurgen Klopp
Chelsea possible starting lineup:
Courtois; Ivanovic, Cahill, Miazga, Azpilicueta; Mikel, Matic, Willian, Fabregas, Hazard; Costa
Manager: Guus Hiddink