Emre Can will start for Liverpool alongsideJames Milner and captain Jordan Henderson in midfield.
Can played the full 90 minutes during Liverpool’s 1-0 victory over FC Augsburg in the Europa League earlier this week.
The Germany international of Turkish origin will also win his first piece of silverware for the Reds should Liverpool beat City today.
Klopp has also given striker Daniel Sturridge who has missed the majority of the season due to injury a place in the starting line-up.
Liverpool v Manchester City
Kick-off: 16:30 (GMT)
Liverpool confirmed line-up: Mignolet, Clyne, Lucas, Sakho, Moreno, Can, Henderson, Milner, Firmino, Coutinho, Sturridge
Subs: Bogdan, Toure, Benteke, Lallana, Allen, Origi, Flanagan
Manager: Jurgen Klopp
Manchester City confirmed line-up: Caballero, Sagna, Kompany (C), Otamendi, Clichy, Fernando, Fernandinho, Toure, Silva, Sterling, Aguero
Subs: Hart, Kolarov, Zabaleta, Demichelis, Navas, Iheanacho, Bony