Emre Can has been included in Jurgen Klopp’s starting line-up in place of the injured Adam Lallana.
United will be without Phil Jones but Jose Mourinho revealed mid-week that Luke Shaw and Henrikh Mkhitaryan have both recovered from injury.
Team captain Wayne Rooney has been left on the bench once again due to being in poor form lately.
Liverpool can move up to the top of the Premier League title if they record a win over their biter rivals tonight.
Liverpool v Manchester United
Liverpool confirmed lineup: Karius, Clyne, Matip, Lovren, Milner, Henderson, Can, Coutinho, Firmino, Mane, Sturridge
Subs: Mignolet, Moreno, Klavan, Lucas, Grujic, Lallana, Origi
Manchester United confirmed lineup: Dea Gea, Valencia, Bailly, Smalling, Blind, Fellaini, Pogba, Herrera, Young, Rashford, Ibrahimovic