Emre Can has been given the nod in Jurgen Klopp’s midfield alongside captain Jordan Henderson.
Klopp will be able to call on star striker Daniel Sturridge after a lengthy injury while in-form attacking midfield Firminho and Lallana also start.
Manchester United will be without their captain Wayne Rooney but in-form youngster Rashford has been given the nod after an impressive run in the first team.
Liverpool v Manchester Utd
Liverpool confirmed line-up: Mignolet, Clyne, Lovren, Sakho, Moreno, Can, Henderson, Lallana, Coutinho, Firmino, Sturridge
Subs: Ward, Toure, Benteke, Allen, Origi, Smith, Ojo
Man Utd confirmed line-up: De Gea, Varela, Smalling, Blind, Rojo, Schneiderlin, Fellaini, Memphis, Mata, Martial, Rashford
Subs: Romero, Darmian, Riley, Carrick, Schweinsteiger, Weir, Herrera